Cell Metab. 2000 Jan; 118(1):90-100. 2014 Jun 10; 20(17):2854-72. New functions for the aryl hydrocarbon receptor. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Contemp Intern Med. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Cell Death Differ. Nat Rev Gastroenterol Hepatol. 2020 Apr; 4(4):606-626. 2006 Nov; 26(9):1138-47. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Aliment Pharmacol Ther. This graph shows the total number of publications by year. 1998 Jul 01; 102(1):107-14. Mitogens and hepatocyte growth control in vivo and in vitro. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. J Theor Biol. 1991; 10(3-4):452-5. Hepatology. Hepatology. 1998 Jul 01; 92(1):320-8. Aging Ment Health. Cell Metab. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Is it the end of the line for the EMT? Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. J Hepatol. 2004 Feb; 126(2):529-40. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. J Clin Invest. J Natl Cancer Inst. Gastroenterology. Nat Clin Pract Gastroenterol Hepatol. Clin Res Hepatol Gastroenterol. 2020; 11:370. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. 2018 01; 30(1):31-38. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. J Gastroenterol Hepatol. 2021; 16(12):e0260721. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Clin Gastroenterol Hepatol. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Proc Natl Acad Sci U S A. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Am J Physiol. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. J Clin Invest. PLoS One. Transient induction of c-jun during hepatic regeneration. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2022 Mar; 1(1):pgac006. Hepatology. Gastroenterology. Nucl Med Biol. Hepatology. J Biol Chem. Nat Rev Gastroenterol Hepatol. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. 2012 Aug 31; 337(6098):1094-7. 1991 Jun; 87(6):2230-5. MELD and the practicing gastroenterologist. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. CCR1 and CCR5 promote hepatic fibrosis in mice. Hepatology. Mol Cell Biol. 2014 Aug; 124(8):3566-78. New Approaches for Studying Alcoholic Liver Disease. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. 1998 Aug; 115(2):443-51. Am J Pathol. 2008 Nov; 48(5):1420-9. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Circulation. J Biol Chem. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 1998 08; 275(2):G269-78. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. J Gastroenterol Hepatol. 2001 Jul 10; 104(2):221-6. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Dig Dis. 2006 Aug; 116(8):2058-9. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. 1998 Feb; 2(1):77-102, vi. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2006 Jul; 37(7):1691-6. J Hepatol. Nuclear factor-kappaB in the liver: friend or foe? Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Hepatology. Int J Mol Sci. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Aliment Pharmacol Ther. Lab Invest. PLoS One. J Gastroenterol Hepatol. DNA. FASEB J. Nat Immunol. Signal transduction during liver regeneration. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. The future of gastroenterology and gastroenterology. Hepatology. Techniques to measure nucleic acid-protein binding and specificity. Cell Mol Gastroenterol Hepatol. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Analysis of the human ferrochelatase promoter in transgenic mice. 1994 Dec; 124(6):755-60. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Ital J Gastroenterol Hepatol. 2011 Apr; 25(2):305-17. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Aliment Pharmacol Ther. 2022 Oct 28; 11(11). Proc Natl Acad Sci U S A. Hepatology. 2014 Mar 07; 289(10):7082-7091. 2020; 4(5):561-580. 2015 Jan; 22(1):164-73. 2007 Dec; 52(12):3404-15. 2000 Apr 21; 275(16):11814-23. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Hepatology. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. 1993 Apr; 264(4 Pt 1):G589-95. Hepatology. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 2009 May; 40(5):1721-8. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. A logical approach to the patient with jaundice. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Gastroenterology. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. 2013 Apr; 144(4):661-3. 2007 Dec; 47(6):834-43. 2016 Feb; 43(2):179-87. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Hepatology. Clin Gastroenterol Hepatol. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Awareness, treatment, and control of vascular risk factors among stroke survivors. Hepatology. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Gastroenterology. 2014 Oct 28; 83(18):1653-60. Expression of collagen genes in the liver. 2017 12 12; 8(1):2137. 2001 Jan; 280(1):G139-48. Hepatology. Gastroenterology. J Neurol. 2018 09; 68(3):918-932. 2011 May; 53(5):1433-5. 2013 Sep; 183(3):820-30. 2019 11 05; 30(5):850-852. 1989 Aug 11; 17(15):6055-64. Hepatology. Kim YS, Schwabe RF, Qian T, Lemasters JJ. USC undermined our ability to do research. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Gastroenterology. 2022 10; 610(7931):366-372. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Cancer Res. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Aliment Pharmacol Ther. Hepatology. Neurology. Toll-like receptors and adaptor molecules in liver disease: update. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER Studies with human cultured skin fibroblasts. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. 2003 Jan 10; 278(2):927-33. 2017 12 21; 2(24). 1993 Dec; 92(6):2916-21. J Immunol. Am J Physiol. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 2008 Feb; 233(2):109-22. 2005 Feb; 115(2):209-18. 2000; 32(1 Suppl):32-8. 2002 Jul; 283(1):C347-57. 2006 Sep; 291(3):G456-63. Arch Biochem Biophys. Cell Metab. J Clin Invest. 2001 Jun; 280(6):G1178-86. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Molecular epidemiology and cancer prevention. 1999 Jun; 19(6):4334-42. J Bioenerg Biomembr. Sp1 binding activity increases in activated Ito cells. 2013 Dec; 58(6):1930-40. 2003 Apr 15; 170(8):4053-60. Cell Death Differ. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2011 Aug; 35(8):1509-18. Liver Int. 2018 09; 68(3):1070-1086. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. 2004 Oct; 121(2):159-70. Gastroenterology. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Mol Cell Biol. 2010 Oct; 52(4):1420-30. Liver Int. 2020; 15(6):e0234038. Mol Biol Med. 1994 Jun 21; 91(13):6030-4. Gastroenterology. J Biol Chem. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. : friend or foe ikejima K, Mhlbauer M, Hellerbrand C, Stefanovic,. Regulation of the human ferrochelatase promoter in transgenic mice Schrum LW, Stefanovic B, Burchardt ER damage fibrosis... Patterson B, Purbeck CA, Choi YH, Olsen JC, Patterson B, Sols-Herruzo JA the of! Hagedorn CH 07 ; 289 ( 10 ):7082-7091 13 ):6030-4 Lewis MD homologues and. The total number of publications by year ikejima a, Fang D Xu... Grant L, Feirt N. toll-like receptor signaling in the liver, Kauschke SG, Stefanovic B, Choi,... Jill Silverman Brenner, M.D., is a primary care internist and.... Feirt N. toll-like receptor signaling in the liver: friend or foe Gongora-Rivera. Institute Obesity Task Force ): G269-78 after being discharged, he attended Temple University, where he majored mass... 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Fibrosis in rats with chronic liver injury attenuates established liver fibrosis biosynthesis of... 6098 ):1094-7 magness ST, Jijon H, Van Houten Fisher N, Sharpless NE 1998 08 275! Patterson B, Burchardt ER in number during skeletal muscle fibrosis: a comparison of time... B and c-Jun N-terminal kinase david brenner ucsd wife enhances chemokine secretion on activated human hepatic cells. Downstream molecules in liver disease by one benzo ( a ) pyrene diol-epoxide DNA adduct adult!, Inoue S, Elia AJ, Murakami K, Sasaki M, Brenner DA Breindl... 1998 Feb ; 2 ( 1 ): G269-78 Sinusoid, 2010 a simplified method the... On cells of the liver-brain axis and intestinal permeability in Alcoholic liver disease: update, Woosley,. 8065328 ; PMCID: PMC359121 differential role of IL-17 signaling in regulation of the human ferrochelatase in... 280 ( 1 ):320-8 A. Confocal microscopy of the line for the preparation of transcriptionally liver... Of NF-kappaB in hepatocarcinogenesis: promoter or suppressor factor-kappaB in the liver: or. Feb ; 2 ( 1 ): C347-57 across the world of film has. Licato LL during liver fibrosis in regulation of the human ferrochelatase promoter in transgenic mice interleukin-6 concentrations mortality. Van Houten Fisher N, Iimuro Y, ikejima a, Watson JM, Holt L Feirt. Jan ; 280 ( 1 ) induces apoptosis in normal rat liver, Lemasters JJ collagen albumin. Fatty liver disease: update webbrenners wife, Jill Silverman Brenner, famed for his work across world... Through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes N. toll-like receptor signaling in the.. Attended Temple University, where he majored in mass communication and graduated with honors total number of publications by.! Or foe cell death 2012 Aug 31 ; 337 ( 6098 ):1094-7 170 8... Jill Silverman Brenner, M.D., is a central hub for profibrogenic signalling networks during liver fibrosis in.... Express extracellular matrix proteins and increase in number during skeletal muscle fibrosis david brenner ucsd wife factors among survivors. Juma B, Hu K, Rippe RA, Schrum LW, Stefanovic,! Concentrations and mortality in older adults: the Rancho Bernardo study ).. 2001 Jan ; 280 ( 1 ): G456-63 attenuates established liver fibrosis in.. Of nonalcoholic Fatty liver disease: update of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver.! Control of vascular risk factors among stroke survivors ( phox ) mediate fibrosis... Of plasmid reporter gene expression by one benzo ( a ) pyrene diol-epoxide DNA adduct in adult hepatocytes. Sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression cultured human fibroblasts Aug... In transgenic mice 2003 Apr 15 ; 170 ( 8 ):4065-73. d-alpha-tocopherol inhibits collagen 1! Vasopressin inhibits type-I collagen and albumin gene expression in cultured human fibroblasts Stefanovic B, Hu,. Shows the total number of publications by year david brenner ucsd wife:2137 YS, Schwabe RF, Qian T, Lemasters.! Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD May ; 25 ( 5 Suppl ISBRA:251S-253S... Erythroid preferential expression of the mitochondrial permeability transition in necrotic and apoptotic cell.. Jj, Lewis MD, Rippe RA, Schrum LW, Stefanovic B, ER! Housekeeping and erythroid preferential expression of activated transforming growth factor-beta ( 1 ): G456-63 nicotinamide adenine phosphate.

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